There’s research showing that taking creatine for depression could relieve symptoms.

Find out what the latest science says.

But the rest goes to other tissues, including your brain.

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Evidence has shown that major depressive disorder is linked with impaired energy metabolism in the brain, Sultan explains.

Supplementing with creatine might work by helping restore energy balance within the brain.

For people already battling depression, creatine supplementation was shown to enhance antidepressant response in a 2023reviewpublished inSports Medicine.

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assistant professor of clinical psychiatry and director of the Mental Health Informatics Lab at Columbia University

Creatines therapeutic effects may go beyond energy metabolism, too.

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LOS ANGELES - FEB 10: Patrick Schwarzenegger at the White Lotus Season 3 Premiere at Paramount Studios on February 10, 2025 in Los Angeles, CA

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